Lisa Little holds a Master of Architecture from the Southern California Institute of Architecture (SCI-Arc) and a Bachelor of Science in electrical engineering from Georgia Institute of Technology.  Little integrates her engineering and architecture backgrounds to create an atypical approach to her research and design projects. Her work strives to engage ambient phenomena through built form. She is principal of her own architecture practice, Vertebrae and was a co-founder of Layer.

Recent projects include private residences, large scale artworks, and commercial interiors and have appeared in the LA Times Home section, Interior Design, The California Design Biennial and numerous museums and galleries.  Before founding Vertebrae and Layer, Little worked at Patrick Tighe Architecture and Pugh+Scarpa.  She has also worked as the director of software development teams and as a hardware design engineer in the field of film and television postproduction.  Little currently teaches graduate and undergraduate level design studios at the University of Southern California and is a licensed architect in the state of California.